At Best Startup California we track over 300,000 Californian startups and over 1,500,000 people who hold key positions in these companies. We use this directory of startups to highlight top employees, founders and organisations we think deserve more appreciation than they are currently getting.
We’ve ranked the top 55 Therapeutics companies in South San Francisco, California. The companies, startups and institutions listed in this article are all exceptional companies, well worth a follow. We have included links to their websites, socials and CrunchBase (if you’re interested in their financials).
We selected the organisations listed in this article based on:
- Track record
- Executive leadership
- Market share
- Innovation
- ESG rating
Our Data – We source our data from OSINT (open source intelligence) and public directories such as Crunchbase, SemRush and many more. The data from these sources should be treated with a degree of caution and verified yourself.
Top Therapeutics Companies & Startups (South San Francisco, California)
Annexon Biosciences
Annexon Biosciences is a biotech company, discovering and developing novel therapeutics for neurodegenerative and autoimmune disorders.
Founder(s): Arnon Rosenthal, Ben Barres
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Health Diagnostics, Life Science, Therapeutics
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Catalyst Biosciences
Catalyst Biosciences is a drug R&D company creating catalytic biopharmaceutical products based on engineered human proteases.
Founder(s): Charles S. Craik, Christopher Thanos, Jack Nguyen, Sandra Waugh Ruggles
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Life Science, Medical, Medical Device, Pharmaceutical, Therapeutics
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Ambys Medicines
Ambys Medicines is a biotechnology company focused on discovering and developing regenerative and restorative therapies.
Founder(s): Holger Willenbring, Juan Carlos Izpisua Belmonte, Markus Grompe, Martin Burke
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Calithera Biosciences
Calithera is a pharmaceutical company developing novel small molecule therapeutics for the treatment of cancer.
Founder(s): Susan M. Molineaux
Location: South San Francisco, California, United States
Industries: Biotechnology, Pharmaceutical, Therapeutics
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Novome Biotechnologies
Novome Biotechnologies is a biotechnology company focused on engineering defined activities into the human.
Founder(s): Liz Shepherd, Weston Whitaker, Will DeLoache, Zachary Russ
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Therapeutics
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CODA Biotherapeutics
CODA Biotherapeutics develops a chemogenetic platform designed to modulate neuronal activity.
Founder(s): Joseph Glorioso, Kenneth Greenberg, Nicholas Boulis
Location: South San Francisco, California, United States
Industries: Biotechnology, Genetics, Medical, Therapeutics
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ORIC Pharmaceuticals
ORIC Pharmaceuticals operates as a biopharmaceutical company.
Founder(s): Charles Sawyers, Scott Lowe
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Pharmaceutical, Therapeutics
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Federation Bio
Federation Bio is a microbial therapeutics company targeting diseases in which the human microbiome can play a curative role.
Founder(s): Dylan Dodd, Michael Fischbach, Racquel Bracken
Location: South San Francisco, California, United States
Industries: Biotechnology, Life Science, Therapeutics
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Interline Therapeutics
Interline Therapeutics is a drug discovery platform that enables the company to map and correct dysfunctional protein communities.
Founder(s): Zach Sweeney
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Medical, Therapeutics
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Blade Therapeutics
Blade Therapeutics is a discovery stage drug development company.
Founder(s): Harry Dietz
Location: South San Francisco, California, United States
Industries: Biopharma, Health Care, Pharmaceutical, Therapeutics
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Stemcentrx
Stemcentrx provides pharmaceutical services.
Founder(s): Brian Slingerland, Scott J. Dylla
Location: South San Francisco, California, United States
Industries: Alternative Medicine, Biotechnology, Health Diagnostics, Pharmaceutical, Therapeutics
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Rapt Therapeutics
Rapt is focused on the discovery and development of novel small-molecule agents to activate the immune system to eradicate cancer.
Founder(s): Brian Wong
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Medical, Pharmaceutical, Therapeutics
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Zenflow
Zenflow is a medical company that gives new hope to men suffering from BPH symptoms.
Founder(s): Nick Damiano, Shreya Mehta
Location: South San Francisco, California, United States
Industries: Health Care, Medical Device, Therapeutics
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Portola Pharmaceuticals
Portola Pharmaceuticals develops therapeutics for acute and chronic cardiovascular, and autoimmune and inflammatory diseases.
Founder(s): Charles Homcy, David Phillips
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Therapeutics
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Rigel Pharmaceuticals
Rigel Pharmaceuticals develops small-molecule drugs for the treatment of autoimmune diseases, cancer and metabolic diseases.
Founder(s): Thomas A. Raffin
Location: South San Francisco, California, United States
Industries: Biotechnology, Pharmaceutical, Therapeutics
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Swiftscale Biologics
Swiftscale Biologics uses cell-free protein synthesis to enable the next generation of protein therapeutics.
Founder(s): David Mace, Matthew Delisa, Michael Jewett
Location: South San Francisco, California, United States
Industries: Big Data, Bioinformatics, Biopharma, Biotechnology, Therapeutics
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Amphivena Therapeutics
Amphivena Therapeutics is a clinical-stage immuno-oncology company that develops a platform of dual-function biologics.
Founder(s): Luke Evnin
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Therapeutics
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Cero Therapeutics
CERo Therapeutics, Inc. is a new cellular immunotherapy company.
Founder(s): Daniel Corey
Location: South San Francisco, California, United States
Industries: Biotechnology, Therapeutics
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Kezar Life Sciences
Kezar Life Sciences company focused on the discovery and development of drugs targeting protein homeostasis for autoimmune disorders
Founder(s): Christopher Kirk, Jack Taunton, John Fowler
Location: South San Francisco, California, United States
Industries: Health Care, Health Diagnostics, Life Science, Therapeutics
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Tizona Therapeutics
Tizona develops next-generation immunotherapies
Founder(s): Charles Drake, Dario Vignali, Drew Pardoll, Jedd Wolchok, Vijay Kuchroo
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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GigaGen
GigaGen specialized in the early discovery and development of recombinant biotherapeutic medicines.
Founder(s): David Johnson, Everett Meyer
Location: South San Francisco, California, United States
Industries: Biotechnology, Genetics, Medical, Therapeutics
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Satsuma Pharmaceuticals
Satsuma Pharmaceuticals is a clinical-stage biopharmaceutical company engaged in developing a novel therapeutic product.
Founder(s): John Kollins
Location: South San Francisco, California, United States
Industries: Biotechnology, Pharmaceutical, Therapeutics
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Medeor Therapeutics
Medeor Therapeutics is a biotechnology company that dedicates to dedicates to the development of personalized cellular immunotherapies.
Founder(s): Chih-Ping Liu, Edgar Engleman, Robert Lowsky, Samuel Strober, Steven Deitcher
Location: South San Francisco, California, United States
Industries: Biotechnology, Pharmaceutical, Therapeutics
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Iconic Therapeutics
Iconic Therapeutics develops and commercializes immunoconjugate proteins that trigger the immune system to destroy invader cells.
Founder(s): Kirk Dornbush, Michael Sherman
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Therapeutics
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Alios BioPharma
Alios BioPharma is a biotechnology company developing novel medicines for the treatment of viral diseases.
Founder(s): John Donovan, Lawrence Blatt, Leonid Beigelman
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Therapeutics
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Atara Biotherapeutics
Atara Biotherapeutics (Nasdaq: ATRA) is an off-the-shelf, allogeneic T-cell immunotherapy company.
Founder(s): Isaac Ciechanover
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Therapeutics
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IDEAYA Biosciences
IDEAYA Biosciences is an oncology-focused biotechnology company committed to the discovery of breakthrough synthetic lethality
Founder(s): Jeffrey Hager, Yujiro S. Hata
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Therapeutics
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Tolerion
Tolerion is a biotechnology company addressing the cause of autoimmune diseases through bio-therapeutic.
Founder(s): Larry Steinman
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Titan Pharmaceuticals
Titan Pharmaceuticals develops proprietary therapeutics for the treatment of serious medical disorders.
Founder(s): Louis Bucalo
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Maze Therapeutics
Maze Therapeutics is an operator of a biotechnology firm used to focus on translating genetic insights into new medicines.
Founder(s): Charles Homcy
Location: South San Francisco, California, United States
Industries: Biotechnology, Therapeutics
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Amunix
Amunix is a biopharmaceutical company intended to discover, design, and develop novel biologics, protein, and peptide therapeutics.
Founder(s): Volker Schellenberger
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Encoded Therapeutics
Encoded Therapeutics is a Harnessing the regulatory genome to create next-generation molecular therapies.
Founder(s): Kartik Ramamoorthi, Stephanie Tagliatela
Location: South San Francisco, California, United States
Industries: Biotechnology, Genetics, Health Care, Therapeutics
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Emerald Cloud Lab
Emerald Cloud Lab is building technology platforms to drive the future of biotechnology innovation.
Founder(s): Brian Frezza, DJ Kleinbaum
Location: South San Francisco, California, United States
Industries: Biotechnology, Industrial Automation, Medical, Robotics, Therapeutics
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Cellares
Cellares is a life sciences technology company that develops the Cell Shuttle to automate cell therapy manufacturing.
Founder(s): Alex Pesch, Fabian Gerlinghaus, Omar Kurdi
Location: South San Francisco, California, United States
Industries: Biotechnology, Life Science, Manufacturing, Medical, Therapeutics
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Pliant Therapeutics
Pliant Therapeutics focuses on discovering, developing, and commercializing breakthrough treatments for fibrotic diseases.
Founder(s): Bill DeGrado, Bradley Backes, Dean Sheppard, Hal Chapman
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Health Diagnostics, Pharmaceutical, Recruiting, Therapeutics
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Pionyr Immunotherapeutics
Pionyr Immunotherapeutics is a developer of cancer immunotherapies designed to target the tumor microenvironment.
Founder(s): Max Krummel, Sachdev Sidhu
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Pharmaceutical, Therapeutics
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Senti Biosciences
Senti Biosciences is a developer of a programmable biology platform for cancer therapies.
Founder(s): Jim Collins, Philip Lee, Timothy K. Lu, Wilson Wong
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Medical, Therapeutics
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CytomX Therapeutics
CytomX Therapeutics is a biotechnology company that focuses on developing proteolytically-activated antibodies.
Founder(s): Fred Gluck, Patrick Daugherty
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Pharmaceutical, Therapeutics
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Harpoon Therapeutics
Harpoon Therapeutics is a clinical-stage immunotherapy company developing novel T cell engagers (TriTACs) for the treatment of cancer.
Founder(s): Luke Evnin, Patrick Baeuerle
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Therapeutics
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GenEdit
GenEdit develops next generation therapeutics for genetic diseases through safe and efficient CRISPR/Cas9 delivery.
Founder(s): Hyo Min Park, Kunwoo Lee, Niren Murthy
Location: South San Francisco, California, United States
Industries: Biotechnology, Genetics, Pharmaceutical, Therapeutics
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Sonoma BioTherapeutics
Sonoma BioTherapeutics develops adoptive Treg therapies cell for autoimmune.
Founder(s): Alexander Rudensky, Fred Ramsdell, Jeffrey Bluestone, Qizhi Tang
Location: South San Francisco, California, United States
Industries: Biotechnology, Life Science, Therapeutics
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AvidBiotics
AvidBiotics is a biotherapeutics company deploying a biotechnology-derived technology platform with multiple apps in life sciences.
Founder(s): David Martin, Jeffery Miller, Jim Knighton
Location: South San Francisco, California, United States
Industries: Biotechnology, Life Science, Therapeutics
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Applied Molecular Transport
Applied Molecular Transport developing novel, oral biological therapeutics to treat severe autoimmune, metabolic and inflammatory diseases.
Founder(s): Randall Mrsny, Tahir Mahmood
Location: South San Francisco, California, United States
Industries: Biotechnology, Therapeutics
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Hyperion Therapeutics
Hyperion Therapeutics is a biopharmaceutical company focused on creating treatments for urea cycle disorders and other rare diseases.
Founder(s): Mark Blumling
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Health Care, Therapeutics
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KAI Pharmaceuticals
KAI Pharmaceuticals discovers and develops novel therapeutics for cardiovascular diseases, kidney diseases and pain.
Founder(s): Daria Mochly-Rosen, Leon Chen
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Axys Pharmaceuticals
AXYS Pharmaceuticals is engaged in the discovery and development of therapeutic small molecules.
Founder(s):
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Raven Biotechnologies
Raven biotechnologies is focused on the development of monoclonal antibody therapeutics for the treatment of cancer.
Founder(s): Jennie P. Mather
Location: South San Francisco, California, United States
Industries: Biotechnology, Medical, Therapeutics
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Anesiva
Anesiva, Inc., a biopharmaceutical company, engages in the development and commercialization of novel therapeutic treatments for pain
Founder(s): John McLaughlin
Location: South San Francisco, California, United States
Industries: Biotechnology, Genetics, Health Care, Medical, Therapeutics
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TALON THERAPEUTICS
Talon Therapeutics is a biopharmaceutical company offering products for clinical development.
Founder(s):
Location: South San Francisco, California, United States
Industries: Biopharma, Biotechnology, Therapeutics
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Cerimon Pharmaceuticals
Cerimon Pharmaceuticals develops and commercializes therapeutics for autoimmune diseases, inflammation, and pains.
Founder(s): Ansbert Gadicke, Luke Evnin, Paul Sekhri
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Pharmaceutical, Therapeutics
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Parvus Therapeutics
Parvus Therapeutics is a novel class of therapeutics to reverse autoimmune disease without impairing normal immunity.
Founder(s):
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Therapeutics, Wellness
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Oncology Therapeutics Network
Oncology Therapeutics Network
Founder(s):
Location: South San Francisco, California, United States
Industries: Health Care, Medical, Therapeutics
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OrganOmics
OrganOmics engages in drug discovery rooted in precision medicine.
Founder(s):
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Care, Medical, Therapeutics
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iZumi Bio
IZumi Bio, a biotechnology company, employs cellular reprograming for the development of stem cell-based therapeutics.
Founder(s):
Location: South San Francisco, California, United States
Industries: Biotechnology, Health Diagnostics, Therapeutics
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Insitro
Insitro is a drug discovery and development startup that utilizes machine learning and biology to transform drug discovery.
Founder(s): Daphne Koller
Location: South San Francisco, California, United States
Industries: Biotechnology, Life Science, Machine Learning, Pharmaceutical, Therapeutics
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